Lab Out 2022 – Canoeing on River Elbe
With 33 degrees Celsius, we enjoyed a refreshing breeze on a day out of the lab on the water of the River Elbe. Our tour…
Belgian waffles
Middle of July, resident doctor and current MES member Frederike Weber celebrated her successful doctoral graduation (back in her former home university Göttingen) providing a…
Expression signature of ECM genes predicts clinical course of patients suffering of deadly cancer
We have described the hitherto unrecognized potential of elevated expression levels of certain extracellular matrix (ECM) genes in brain tumor tissue to be of predictive…
Drug development: Establishment of new gene-therapeutics candidate belonging to the class of polycatisonic phosphorus dendrimer
Herein, we performed the validation of the polycationic phosphorus dendrimer-based approach for small interfering RNAs delivery in cancer stem cell in vitro. As a molecular…
Drug development: Synthesis of a new stem cell-directed, anti-metabolic drug
The failure of a long-lasting curative therapeutic benefit of currently applied chemotherapies against malignant cancers is suggested to be caused by the ineffectiveness of such…
Publication: Development of synthetic human cancer stem cell platform
Limitations in genetic stability and recapitulating accurate physiological disease properties challenge the utility of patient-derived (PD) cancer models for reproducible and translational research. A portfolio…
Signal transmitting neuron or nerve cell- 3d illustration
New publication on “sensory ion channel” as a biomarker for clinical course in PDAC
Our computational pipeline constructed a gene signature that enables us to predict clinical prognostic value of hitherto unrecognized biomarkers for PAAD. Sensory ion channels TRPC3…
New co-authored publication on redox signaling
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the…
New publication on WNT signaling
Collaborative paper with Margriet Ouwens, German Diabetes Center Düsseldorf and Or Kakhlon, Hadassah Medical Center in Jerusalem identifying the cardinal role of canonical WNT signaling…